Tjapaltjarri paints abstract images of sacred stories and songs from his family's Dreaming. The stories focus around the Tingari, the ancestors of the Pintupi, spirit beings who are believed to have created all living things. His stories are about his country and sacred sites such as Marruwa and Kanapilya.
His work is held in several major public collections across Australia, such as in the National Gallery in Canberra, the Art Gallery of New South Wales, and the National Gallery of Victoria. He also has work in galleries overseas, such as the Quai Branly Museum in Paris.